Atletico Madrid could see their Champions League campaign ended at the first hurdle on Wednesday night when they welcome free-scoring Roma to the Estadio Metropolitano.
Diego Simeone’s men find themselves in a rut heading in to Matchday Five, struggling to settle in to their new surroundings after the move from the Vincente Calderon, while star striker Antoine Griezmann has not found the net since September.
Atleti have yet to win in Europe this season, being surprisingly held to two draws by Champions League new boys Qarabag, results that will likely see them drop in to the Europa League.
Los Colchoneros find themselves four points behind second-placed Chelsea, needing to beat the Giallorossi and hope Qarabag do them a favour against the Premier League champions.
However, they face an in-form Roma side, fresh off a Derby della Capitale win over Lazio at the weekend and hammered Chelsea 3-0 last time out in Europe.
The Italians have also won six of the last seven away matches and are 7/2 to become the second team to win at the Metropolitano, which hasn’t witnessed a home win in five matches.
The last four home games for Atleti have ended in draws and another tie at 49/20 is the choice here.
Elsewhere, Manchester United to win at Basel at 1/1 appeals given their good run in Europe this season.
Jose Mourinho’s team have won four out of four to put them within touching distance of a place in the Champions League last-16, a run which included a 3-0 win over Basel at Old Trafford.
The Swiss still have aspirations of going through but their record at home in Europe is poor, losing three of the last four.
The showpiece game of the night pits last season’s runners-up Juventus against Barcelona with the Italians in need of a win to be sure of qualification.
Sporting Lisbon are chasing the Serie A champions and should justify being 1/2 favourites to beat Olympiakos at home, meaning Juve need a good performance.
Barcelona are flying in La Liga, winning 11 out of 12, and beat the Italian champions 3-0 at the Nou Camp on Matchday One.
However, Juventus are unbeaten in 25 home European matches and thrashed the Blaugrana on their last visit to Turin in April.
With all that in mind, the draw and both teams to score at 33/10 looks a solid choice.
Finally, Benfica seem unlikely to be excited about a cold night out in Moscow given they are already eliminated from contention for even a Europa League place.
The Portuguese have lost four out of four and with CSKA in need of the points in the hunt for a last-16 spot, a home win at 23/20 takes the fancy.
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