Twelve teams stand just one hurdle away from the huge prize of a place in the group stages of the Champions League, with a number of former winners amongst them.
Ajax claimed three consecutive European Cup victories in a row in the early 1970s and, while those glory days are long gone, they appear well-placed to see off Dynamo Kyiv in the play-off round and reach the next stage.
A home first leg on Wednesday does not do them any favours, but in Klaas-Jan Huntelaar and Dusan Tadic they have potent attacking options, with the former having already scored four European goals this season.
Veteran Huntelaar is too skinny at 1/1 to score at any time, so 33/10 to open the scoring will offer the opportunity of a better return, while Tadic at 2/1 to score at any time is also worthy of attention.
Hungarian champions MOL Vidi face AEK Athens in the second tie of the evening, while the final clash sees Young Boys play host to a classy and dangerous Dinamo Zagreb outfit.
The Croats have seen off Hapoel Beer Sheva and FC Astana in the last two rounds and have done so in some style, but will need to step up another level against their Swiss opponents who have opened their domestic league season with four wins out of four.
A draw in Bern, available at 29/10, would be a tremendous result for the visitors and Dinamo have the talent to be able to secure such a positive result.
The three games on Tuesday evening include ties for PSV Eindhoven, Benfica and Crvena Zvezda.
PSV head to Belarus to take on BATE Borisov, having won both of their opening two games in the Eredivisie, with Mexican forward Hirving Lozano on target in both of those victories.
Benfica play host to PAOK Salonika in what looks to be a tough test, with the Greeks having already knocked out both FC Basel and Spartak Moscow.
The Lisbon Eagles are the team fancied to progress to the group stage, but do not overlook PAOK (27/10), especially with the second leg back in their homeland where a fiery atmosphere is something of a given.
Finally, Crvena Zvezda are at home in their first leg against RB Salzburg, who reached the Europa League semi-finals last season and who have won all seven games they have played this season.
At 11/10 to win in Belgrade they certainly have plenty going for them.
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