The Baltimore Ravens enjoyed a faultless pre-season campaign, with five wins out of five, and so a home game with the Buffalo Bills offers a perfect opportunity to start the NFL campaign with another victory.
The Bills finally ended their long wait for a post-season spot last season but appear unlikely to repeat the feat again this term.
Baltimore to win by 13-18 points – 16/5
The Ravens will be hoping to end a run of three straight seasons without post-season action and, having finished the regular season 9-7 last term, only a minor improvement is needed to ensure that target is met.
It looks like it can be achieved, with the Chicago Bears, Los Angeles Rams, Indianapolis Colts, Miami Dolphins and the Washington Redskins all vanquished in pre-season action.
Double Result – 49ers/Vikings – 11/2
An interesting match-up takes place at the US Bank Stadium in Minneapolis, where the Minnesota Vikings welcome the San Francisco 49ers.
The hosts, who reached the NFC Championship game last season, have recruited quarterback Kirk Cousins from the Redskins, a move which sees them fancied by many as potential winners of Super Bowl LIII.
The visiting 49ers are a franchise revitalised by a quality quarterback of their own in the shape of former Tom Brady back-up Jimmy Garoppolo.
He moved to The Bay just under a year ago and made a huge impact, leading the 49ers to a regular season record of 6-10, which looked likely to be a lot worse when the team lost their opening nine games of the campaign.
Now Garoppolo has the chance to shine over the course of an entire season and how he and his team get on against the Vikings should give plenty of clues as to what lies in store.
Green Bay to win by 7-12 points – 7/2
The late game on Sunday sees the fancied Green Bay Packers play host to the Chicago Bears at Lambeau Filed.
Both franchises have been splashing the cash in recent times, with the Bears acquiring Khalil Mack from the Oakland Raiders to become the highest-paid defensive player in the NFL.
However, at quarterback Chicago have the inexperienced Mitch Trubisky, while the Packers have the vast knowledge of Aaron Rodgers to call on.
He also recently secured a massive new contract and he and a talented offensive line should have far too much firepower for the Bears, who may be one of the teams to watch next season, but not just yet.
For all new customers, ComeOn! are currently offering a £10 free bet – make sure you sign up!