All eyes will be on Old Trafford when Manchester United take on Valencia and the Spanish side can add to Jose Mourinho’s problems by drawing their Champions League clash.
Los Che have been the embodiment of solidity so far this season, drawing five of their seven La Liga matches, scoring five times and conceding just six goals.
They ground out a 1-0 victory at Real Sociedad on Saturday and are more than capable of nicking a point against a United side that seemed disinterested and poorly organised at West Ham.
Elsewhere in Group H it is a case of how many goals Juventus will score against Young Boys – a win for the Serie A side by three goals is available at 33/10 – while in Group G, Manchester City can get back on track following their shock home loss to Lyon by beating Hoffenheim.
Lyon may struggle against Shakhtar Donetsk in their second match with a draw available at 14/5, while Real Madrid should have little difficulty beating CSKA Moscow in the Russian capital.
Also in Group G, Roma have hit form after making a slow start to the campaign and have beaten Frosinone 4-0 and Lazio 3-1 in their last two Serie A matches.
They should have too much quality for Czech champions Viktoria Plzen who drew 2-2 with CSKA a fortnight ago.
Two teams that dominated the European Cup in the 1970s meet in Group E when Bayern Munich take on Ajax.
The Dutch side won three European Cups in a row between 1971 and 1973 before Bayern triumphed in the next three.
Ajax are no longer a force in European football and Bayern, despite losing at Hertha Berlin on Friday, should be able to ease to a routine victory on home soil.
Elsewhere in that pool, Benfica need to bounce back after losing 2-0 at home to Bayern a fortnight ago but they may have to settle for a draw in Greece, available at 9/4, when they take on AEK Athens, who knocked Celtic out in the third qualifying round.
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